PRO33 - AN OVERVIEW

max in WT synaptoneurosomes, suggesting that Src signaling may very well be downregulated in KI synapses. On the other hand, our power to rescue SERT function in KI midbrain synaptoneurosomes from the inhibition of FAK indicates elevated FAK signaling downstream in the Pro32Pro33 mutant, as confirmed by elevated pFAK localization in 5-HT synapses.